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FOLFIRI + bevacizumab
- Development stage
- Unknown
- Lead developer
- Genentech
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Recombinant Proteins and Enzymes, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
FOLFIRI + bevacizumab is a combination chemotherapy and targeted therapy regimen used primarily for the treatment of metastatic colorectal cancer. The regimen consists of four drugs: - Bevacizumab, a monoclonal antibody that inhibits vascular endothelial growth factor (VEGF), thereby blocking angiogenesis and reducing tumor blood supply. - Fluorouracil (5-FU), an antimetabolite that incorporates into DNA and RNA to inhibit cell division. - Irinotecan, a topoisomerase I inhibitor that prevents DNA from uncoiling and duplicating. - Leucovorin (folinic acid), which enhances the effectiveness of fluorouracil. This combination works synergistically by attacking cancer cells through different mechanisms—chemotherapy agents disrupt DNA synthesis and cell division, while bevacizumab targets tumor vasculature. It is administered intravenously in cycles every two weeks. The primary indication is metastatic colorectal cancer; it may also be used for other gastrointestinal cancers such as appendiceal adenocarcinoma and small bowel adenocarcinoma[1][2][4][5][8].
- Brand names
- Avastin (for bevacizumab)Camptosar (for irinotecan)
- Other names
- folfiri-bevacizumab regimenbevacizumab-folfiri
02
Targets
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