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FOLFOX + sunitinib
- Development stage
- Preclinical
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intravenous, Oral
01
Overview
FOLFOX + sunitinib is a combination regimen consisting of the chemotherapy protocol FOLFOX (folinic acid, fluorouracil, and oxaliplatin) plus the targeted therapy sunitinib. - **FOLFOX** is a standard chemotherapy regimen primarily used for colorectal cancer. It combines three drugs: - Folinic acid (leucovorin): enhances the effectiveness of fluorouracil. - Fluorouracil (5-FU): an antimetabolite that inhibits DNA synthesis in rapidly dividing cells. - Oxaliplatin: a platinum-based agent that causes DNA crosslinking and apoptosis in cancer cells[1][2][4][7]. - **Sunitinib** is an oral small molecule tyrosine kinase inhibitor targeting multiple receptors including vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), KIT, FLT3, RET, and CSF1R. It inhibits tumor angiogenesis and cell proliferation. This combination aims to leverage both cytotoxic effects from chemotherapy and antiangiogenic/targeted effects from sunitinib for enhanced anticancer activity.
- Brand names
- Sutent
- Other names
- folinic acid + fluorouracil + oxaliplatin + sunitinib
02
Targets
PDGFRA (Platelet-derived growth factor receptor alpha)TS (Thymidylate synthase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR2 (Vascular endothelial growth factor receptor 2)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)DNAVEGFR3 (Vascular endothelial growth factor receptor 3)CSF1R (Macrophage colony-stimulating factor receptor)RET (Rearranged during transfection receptor tyrosine kinase)FLT3 (Fms related receptor tyrosine kinase 3)
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