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Drug intelligence / Profile preview
folic acid + indocyanine green
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Folic acid-indocyanine green (Folate-ICG) is a tumor-targeted near-infrared (NIR) fluorescent imaging agent. It consists of folic acid, which acts as a targeting ligand for the folate receptor alpha (FRα) overexpressed on various cancer cells, covalently conjugated to the near-infrared fluorophore indocyanine green (ICG). Upon administration, the conjugate selectively binds to folate receptors on tumor cells and is internalized via receptor-mediated endocytosis, allowing for high-contrast, real-time intraoperative fluorescence imaging of FRα-positive malignancies. While closely related to the approved agent pafolacianine (which uses an ICG-like dye), the direct folic acid-ICG conjugate is primarily utilized in preclinical research.
- Other names
- folate-ICGfolate-indocyanine greenfolic acid-indocyanine greenfolic acid-indocyanine green conjugate
02
Targets
FOLR1 (FRα)
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