folic acid + liposomal indocyanine green + cytosine-phosphate-guanine oligodeoxynucleotide

This agent is a **combination nanomedicine platform** composed of three main components: - **Folic acid**, which serves as a ligand for targeting cells that overexpress the folate receptor, commonly found on certain cancer cells[3][7]. - **Liposomal indocyanine green (ICG)**, a clinically used near-infrared (NIR) fluorescent dye encapsulated within liposomes to enhance accumulation in tumor tissue and stability; primarily utilized for imaging and phototherapeutic effects[2][4][8]. - **Cytosine-phosphate-guanine oligodeoxynucleotide (CpG ODN)**, a synthetic oligonucleotide that acts as a Toll-like receptor 9 (TLR9) agonist and can stimulate an immune response (immunotherapy, vaccine adjuvant). This **combination acts by:** - Providing **folate receptor-mediated targeted delivery** to cancer cells[3][7]. - Allowing **optical imaging or image-guided therapy** and **photothermal or photodynamic ablation** upon NIR irradiation via indocyanine green[4][8]. - **Stimulating antitumor immune responses** through CpG ODN’s immunostimulatory activity. This construct is designed primarily for **oncology applications**, enabling targeted imaging, photothermal therapy, and immune activation.