fominoben

Fominoben is a small molecule antitussive agent of the benzanilide class primarily used for the treatment of dry (irritative) cough. It was first introduced in Germany in 1973 and later marketed in Italy and Japan. Fominoben acts centrally to suppress cough and is reported to have respiratory stimulant activity—unlike many other antitussives that act as depressants. Its mechanism includes weak binding to the sigma-1 receptor and possible agonist activity at the benzodiazepine site of the gamma-aminobutyric acid A (GABA A) receptor; this may also confer anxiolytic-like properties. The drug has been marketed under several brand names including Noleptan but appears to be discontinued or withdrawn from most markets[1][2][6]. Adverse effects include appetite suppression, nausea, vomiting, insomnia, irritability, hallucinations; rarer side effects are somnolence and dizziness[1][6].

Brand names

BroncomenalDeronylFinatenNoleptanOleptanTerionTosifarTussirama

Other names

fominoben hydrochloride