Drug intelligence / Profile preview

Foproct

Development stage
Phase 2
Lead developer
Verisfield
Modality
Small Molecules
Administration
Rectal, Topical
01

Overview

Foproct (also spelled Forproct) is a fixed-dose combination rectal cream containing hydrocortisone acetate (1% w/w) and lidocaine (1.5% w/w). It is developed by Verisfield and manufactured by Cana Laboratories and HELP. Foproct is indicated for the local symptomatic relief of hemorrhoids, anal fissures, proctitis, and perianal eczema. Hydrocortisone acetate is a mild corticosteroid that binds to the glucocorticoid receptor, suppressing inflammatory mediators to reduce swelling, redness, and itching. Lidocaine is a local anesthetic that blocks voltage-gated sodium channels, preventing the initiation and conduction of nerve impulses to provide rapid pain and itch relief in the anorectal region.

Brand names
FoproctForproct
Other names
hydrocortisone acetate + lidocainehydrocortisone/lidocainelidocaine + hydrocortisone acetatelidocaine/hydrocortisone acetate
02

Targets

GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)

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