Drug intelligence / Profile preview

forsythiae fructus

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Intravenous (in Some Traditional Formulations)
01

Overview

Forsythiae fructus is the dried fruit of the plant Forsythia suspensa, widely used in traditional Chinese medicine. It is known for its anti-inflammatory, antiviral, antibacterial, antioxidant properties and is traditionally used to clear heat and detoxify the body. It is commonly applied in conditions such as airway illnesses (e.g., bronchiolitis), fever, sore throat, tonsillitis, skin infections (erysipelas), and inflammatory diseases. The active compounds include forsythiasides (notably A and B), phillyrin and phillygenin. Mechanistically it may inhibit NF-κB signaling pathways reducing inflammation and modulate immune responses including induction of interferons to exert antiviral effects. Clinical evidence remains limited but preclinical studies support its pharmacological activities.[1][2][3][5][6]

Other names
forsythia fruitweeping forsythia capsulegolden bellslian qiao连翘
02

Targets

TLR4 (Toll-like receptor 4)NOX2 (NADPH oxidase 2)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)

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