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fosigotifator
- Development stage
- Phase 3
- Lead developer
- Calico
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Fosigotifator is an investigational small-molecule drug developed by AbbVie and Calico Life Sciences. It acts as an activator of eukaryotic initiation factor 2B (eIF2B), a guanine nucleotide exchange factor essential for protein synthesis and a key regulator of the integrated stress response (ISR) pathway. By activating eIF2B, fosigotifator aims to attenuate the ISR pathway and restore normal protein production in stressed nerve cells. The drug is being studied primarily for neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Vanishing White Matter (VWM) disease. In preclinical models, it has shown potential to blunt persistent ISR activity in affected brain regions and improve coordination and movement problems. Fosigotifator is currently undergoing clinical trials but has not yet been approved for use in any country[3][4][5][6][7].
- Other names
- fosigotifator sodium tromethamine
02
Targets
eIF2B (Eukaryotic translation initiation factor 2B)
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