fosmidomycin

Fosmidomycin is a small molecule antibiotic originally isolated from *Streptomyces lavendulae*. It acts as a potent and selective inhibitor of the enzyme 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR, also known as IspC), which is essential in the non-mevalonate (MEP) pathway of isoprenoid biosynthesis. This pathway is present in many bacteria and in the malaria parasite *Plasmodium falciparum*, but not in humans, making DXR an attractive drug target. Fosmidomycin has demonstrated activity against a broad range of Gram-negative enterobacteria and has been investigated for use against uncomplicated *Plasmodium falciparum* malaria, often in combination with clindamycin due to high rates of recrudescence when used alone. It was also previously studied for urinary tract infections but development for this indication was discontinued[2][3][4][5].

Other names

fosmidomycinFosmidomycinaFosmidomycineFosmidomycinum3-(formylhydroxyamino)-propylphosphonic acid mono-sodium salt3-(N-formyl-N-hydroxyamino)-propylphosphonic acid mono-sodium salt