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FOXF1 mRNA nanoparticles
- Development stage
- Preclinical
- Lead developer
- University of Arizona
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Gene Therapies, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
FOXF1 mRNA nanoparticles are a precision gene therapy designed to treat pediatric acute respiratory distress syndrome (PARDS) and acute lung injury (ALI). The therapy utilizes pulmonary endothelial-targeted nanoparticles to deliver stabilized mRNA encoding the FOXF1 transcription factor directly to the lung vasculature. FOXF1 is a critical regulator of lung development and endothelial stability; its expression is significantly reduced during systemic sepsis and inflammatory lung injury. By restoring FOXF1 levels, the treatment promotes the transcriptional activation of the anti-apoptotic gene Bcl2, thereby reducing endothelial cell apoptosis, enhancing vascular barrier function, and mitigating pulmonary leakage. This approach is being developed by researchers at the University of Arizona and Phoenix Children’s Hospital.
- Other names
- FOXF1 mRNA NPFOXF-1 mRNA NPFOXF 1 mRNA NPpulmonary endothelial-targeted nanoparticle delivery of FOXF1 mRNA
02
Targets
FOXO1 (Forkhead box protein O1)Fanconi anemia DNA repair complex proteins
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