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FOXY-5 + FOLFOX
- Development stage
- Unknown
- Lead developer
- WntResearch
- Modality
- Peptides, Small Molecules
- Administration
- Intravenous
01
Overview
**FOXY-5 + FOLFOX** is a combination regimen used in oncology clinical research, especially for colorectal and related cancers. FOXY-5 is a synthetic peptide analogue of Wnt5A, developed to mimic the tumor-suppressor function of the native Wnt5A ligand, which is often lost in various cancers. FOXY-5 is being investigated for its ability to inhibit metastasis and promote cell differentiation through non-canonical Wnt signaling pathways. FOLFOX is a well-established chemotherapy regimen that includes oxaliplatin, fluorouracil (5-FU), and folinic acid (leucovorin). The FOLFOX regimen works by combination cytotoxic mechanisms affecting DNA synthesis and repair, as well as enhancing DNA damage through platinum compounds. This combination aims to capitalize on both targeted anti-metastatic effects (FOXY-5) and cytotoxic chemotherapeutic activity (FOLFOX) for synergy in advanced or metastatic gastrointestinal cancers.
- Brand names
- FOXY-5 (where relevant)
- Other names
- Foxy-5 + 5-FU + leucovorin + oxaliplatin
02
Targets
FZD2 (Frizzled Receptor 2)TS (Thymidylate synthase)FZD5 (Frizzled receptor 5)DNA
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