Drug intelligence / Profile preview

FPE024

Development stage
Unknown
Lead developer
Guangdong Fapon Biopharma
Modality
Trispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
01

Overview

FPE024 is a trispecific antibody drug candidate developed by Guangdong Fapon Biopharma. It functions as a bispecific T-cell engager (BiTE) targeting B-cell maturation antigen (BCMA), CD19, and CD3. The drug acts as an inhibitor of BCMA and CD19 while stimulating CD3, aiming to redirect T cells to eliminate pathogenic B cells implicated in autoimmune diseases such as systemic lupus erythematosus. Its primary therapeutic focus is on immune system diseases, with additional exploration in skin and musculoskeletal disorders. As of the latest update, its highest development phase is discovery[1][2].

02

Targets

BCMA (B-cell maturation antigen)CD3 (T-cell surface glycoprotein CD3)CD19 (B lymphocyte antigen CD19)

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