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FPP29
- Development stage
- Preclinical
- Lead developer
- Southwest Jiaotong University
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
FPP29: sourced facts only. name: "In addition, FPP29 can enhance FOXM1 poly-ubiquitination and induce its degradation through the ubiquitin-proteasome system." [PMID:40505324]; target: "In addition, FPP29 can enhance FOXM1 poly-ubiquitination and induce its degradation through the ubiquitin-proteasome system." [PMID:40505324]; developer: "School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan Province, PR China." [PMID:40505324]; modality: "we designed and synthesized a novel and fully peptide-based PROTAC, FPP29, and evaluated its cytotoxicity and molecular mechanisms in liver cancer HCCLM3 cells." [PMID:40505324]; stage: "In vivo studies in xenograft mice showed that 15 mg/kg FPP29 inhibited tumor growth by 75 % with no apparent toxicity." [PMID:40505324]
02
Targets
FOXM1 (Forkhead box protein M1)
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