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Drug intelligence / Profile preview
FR-S
- Development stage
- Preclinical
- Lead developer
- Universidade Federal de Santa Catarina
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
FR-S is a chemically sulfated derivative of a (1→6)-(1→3)-β-D-glucan isolated from the fruiting bodies of the mushroom *Agaricus subrufescens* (also known as *Agaricus brasiliensis*). It is being investigated as a broad-spectrum antiviral agent and an inhibitor of viral pathogenesis. FR-S has demonstrated significant in vitro and in vivo efficacy against flaviviruses, including Dengue virus (DENV) and Zika virus (ZIKV), by inhibiting viral entry and preventing nonstructural protein 1 (NS1)-mediated endothelial hyperpermeability and vascular leak. Additionally, FR-S has shown activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) by blocking viral adsorption and penetration.
- Other names
- sulfated (1-6,1-3)-beta-D-glucansulfated (1->6)-(1->3)-beta-D-glucansulfated Agaricus brasiliensis glucansulfated Agaricus subrufescens glucansulfated beta-glucan
02
Targets
NS1 (Zika virus nonstructural protein 1)GC (Vitamin D-binding protein)
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