FR900359

FR900359 is a cyclic depsipeptide natural product isolated from the plant *Ardisia crenata*. It acts as a potent and selective pan-Gq protein inhibitor, specifically targeting the Gαq, Gα11, and Gα14 subunits of heterotrimeric G proteins. By blocking Gq-mediated signaling, FR900359 inhibits the downstream activation of phospholipase C and subsequent calcium mobilization. Research has demonstrated its potential in treating conditions characterized by pathological Gq signaling, such as pulmonary hypertension, where it prevents and reverses both vasoconstriction and vascular remodeling. It has shown superior vasodilatory effects compared to standard-of-care treatments like bosentan and sildenafil in preclinical models.

Other names

UBO-QIC