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Drug intelligence / Profile preview
Francisella tularensis LVS vaccine
- Development stage
- Unknown
- Lead developer
- General Dynamics
- Modality
- Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Scarification
01
Overview
The Francisella tularensis Live Vaccine Strain (LVS) vaccine is a live-attenuated bacterial vaccine developed for the prevention of tularemia, a potentially fatal zoonotic disease caused by the highly infectious bacterium *Francisella tularensis*. The LVS strain was originally derived from an attenuated *F. tularensis* subsp. *holarctica* strain. In the United States, it has been maintained as an Investigational New Drug (IND) by the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) primarily for the protection of laboratory personnel and other high-risk individuals. The National Institute of Allergy and Infectious Diseases (NIAID) has collaborated with the DynPort Vaccine Company (DVC) to produce a new, standardized lot of the vaccine (DVC-LVS) using modern manufacturing practices to ensure consistency and safety. The vaccine is administered via scarification and works by inducing both cell-mediated and humoral immunity against the pathogen.
- Other names
- Tularemia LVS vaccineLive Vaccine Strain vaccineFrancisella tularensis live attenuated vaccine
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