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Drug intelligence / Profile preview
Freehit Cold
- Development stage
- Unknown
- Lead developer
- Healthkind Labs
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Freehit Cold is a fixed-dose combination oral tablet developed by Healthkind Labs for the treatment of symptoms associated with the common cold, influenza, and upper respiratory tract infections, such as nasal congestion, headache, fever, and body aches. It contains four active ingredients: nimesulide (a selective COX-2 inhibitor that provides anti-inflammatory and analgesic effects), paracetamol (an analgesic and antipyretic agent), phenylephrine hydrochloride (a selective alpha-1 adrenergic receptor agonist that acts as a nasal decongestant), and caffeine (a central nervous system stimulant and adenosine receptor antagonist that enhances the analgesic efficacy of paracetamol and nimesulide while reducing drowsiness).
- Brand names
- Freehit ColdFreehit-Cold
- Other names
- caffeine + nimesulide + paracetamol + phenylephrinecaffeine + nimesulide + paracetamol + phenylephrine hydrochloridenimesulide + paracetamol + phenylephrine + caffeinenimesulide + paracetamol + phenylephrine hydrochloride + caffeine
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)ADRA1A (α1A)ADRA1B (α1B)ADRA1D (α1D)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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