Drug intelligence / Profile preview

french maritime pine bark extract

Development stage
Phase 3
Lead developer
Horphag Research
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

French maritime pine bark extract is a dietary supplement derived from the outer protective bark of the French Pinus pinaster Aiton (subspecies atlantica), a tree native to coastal southwest France. The most studied and standardized form is known as Pycnogenol. The extract contains 65–75% procyanidins (a type of flavonoid), along with other phenolic compounds such as catechin and epicatechin. It is primarily marketed for its antioxidant and anti-inflammatory properties. Proposed mechanisms include free radical scavenging (antioxidant activity), modulation of inflammatory pathways, improvement in blood flow via effects on vascular endothelium and platelet function, and possible immunomodulatory effects[1][2][3][4][5]. Despite widespread use for conditions like osteoarthritis, chronic venous insufficiency (CVI), asthma, hypertension, cognitive decline/ADHD symptoms in children or adults—and claims regarding cardiovascular health—systematic reviews have found insufficient high-quality evidence to support efficacy for any specific disease[1][7]. It is available over-the-counter as capsules or tablets.

Brand names
PycnogenolOligopinFlavangenol
Other names
maritime pine bark extractPinus pinaster bark extractFrench pinus maritime barkpinus maritimapygenolPYC
02

Targets

15-LOX (Lysyl Oxidase)NOS2 (Nitric Oxide Synthase 2)XO (Xanthine Oxidoreductase)

Beyond the preview

Go deeper on french maritime pine bark extract.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on french maritime pine bark extract.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call