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Frizzled2-Fc
- Development stage
- Preclinical
- Lead developer
- Baylor College of Medicine
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
01
Overview
Frizzled2-Fc (Fz2-Fc) is a recombinant fusion protein consisting of the extracellular domain of the Frizzled-2 receptor fused to an Fc domain. It acts as a soluble decoy receptor or protein "trap" designed to bind Wnt ligands and inhibit Wnt signaling. Although designed to reduce Wnt signaling, preclinical studies in mouse models of osteogenesis imperfecta (OI) have shown that Frizzled2-Fc paradoxically increases bone mass, cortical thickness, and bone strength, potentially through activation of the Wnt/mTORC1 pathway. It is being investigated by researchers at Baylor College of Medicine and the University of Texas Health Science Center at Houston as a potential anabolic therapy for the treatment of osteogenesis imperfecta.
- Other names
- Frizzled-2-FcFrizzled2-FcFrizzled 2-FcFz2-FcFz-2-FcFz 2-Fcrecombinant human Frizzled-2 Fc chimera
02
Targets
Wnt (Wnt ligand)
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