Drug intelligence / Profile preview

frovatriptan

Development stage
Approved
Lead developer
Vernalis
Modality
Small Molecules
Administration
Oral
01

Overview

Frovatriptan is a small molecule pharmaceutical drug used for the acute treatment of migraine headaches in adults, with or without aura. It belongs to the triptan class (selective serotonin receptor agonists) and acts primarily as an agonist at serotonin 5-HT1B and 5-HT1D receptors. Its mechanism of action involves narrowing blood vessels around the brain, inhibiting excessive vasodilation, blocking pain signal transmission in the trigeminal pathway, and reducing release of substances that cause migraine symptoms such as pain, nausea, and sensitivity to light or sound. Frovatriptan is notable for its long half-life among triptans (~26 hours), which may contribute to sustained relief. It does not prevent migraines or reduce their frequency[1][2][4][6].

Brand names
FrovaMigard
Other names
frovatriptan succinate monohydratefrovatriptan succinato monoidrato
02

Targets

HTR7 (5-hydroxytryptamine receptor 7)HTR1B (5-Hydroxytryptamine Receptor 1B)HTR1D (5-hydroxytryptamine receptor 1D)HTR1F (Serotonin 5-HT1F receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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