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fructus tribuli
- Development stage
- Phase 4
- Lead developer
- Herbarium Laboratório Botânico
- Modality
- Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Fructus Tribuli is the dried fruit of the plant *Tribulus terrestris* L., widely used in traditional Chinese medicine (TCM) and Ayurveda. It contains a variety of bioactive constituents, including steroidal saponins (such as protodioscin), flavonoids (kaempferol, quercetin, luteolin), and alkaloids. The drug is primarily investigated for its potential in treating male reproductive disorders, such as oligospermia and erectile dysfunction, by potentially modulating androgen levels or nitric oxide signaling. Additionally, research in animal models suggests that Fructus Tribuli may possess neuroprotective, anxiolytic, and antidepressant properties, possibly mediated through the inhibition of monoamine oxidase A (MAO-A) and antioxidant effects. Clinical trials have explored its efficacy and safety in improving sperm parameters in men with oligospermia.
- Brand names
- TribGokshura
- Other names
- fructus tribuliTribulus terrestrisBai Ji Li白蒺藜Puncture VineGokshura
02
Targets
ABCB1 (P-glycoprotein)CYP3A4 (Cytochrome P450 3A4)
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