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fruquintinib + sintilimab
- Development stage
- Phase 3
- Lead developer
- HUTCHMED
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Fruquintinib + sintilimab is a combination therapy consisting of two agents: fruquintinib, a highly selective oral small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and sintilimab, a fully human monoclonal antibody targeting programmed cell death protein 1 (PD-1). Fruquintinib inhibits tumor angiogenesis by blocking VEGFR-mediated signaling pathways essential for new blood vessel formation in tumors. Sintilimab enhances anti-tumor immune responses by inhibiting the PD-1 pathway, thereby restoring T-cell activity against cancer cells. The combination leverages the synergistic effects of targeted antiangiogenic therapy with immunotherapy to improve outcomes in patients with advanced cancers. It has received conditional approval in China for advanced endometrial cancer with mismatch repair proficient tumors after prior systemic therapy failure and has demonstrated efficacy as second-line treatment for locally advanced or metastatic renal cell carcinoma (RCC) in clinical trials[1][3][4].
- Brand names
- TYVYT + ELUNATE
- Other names
- sintilimab + mFFNsintilimab plus fruquintinib
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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