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fruquintinib + SOX
- Development stage
- Unknown
- Lead developer
- HUTCHMED
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
fruquintinib + SOX is a combination neoadjuvant therapy regimen being evaluated for the treatment of locally advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma. The regimen consists of fruquintinib, a highly selective and potent oral tyrosine kinase inhibitor of VEGFR-1, 2, and 3, combined with the SOX chemotherapy regimen (S-1 plus oxaliplatin). Fruquintinib, developed by HUTCHMED, inhibits tumor angiogenesis, while SOX provides cytotoxic effects through DNA cross-linking (oxaliplatin) and inhibition of thymidylate synthase (S-1). This specific combination is being investigated in a Phase II clinical trial sponsored by Guangxi Medical University to improve R0 resection rates and long-term survival in patients with stage III disease.
- Other names
- Fruquintinib plus SOXFruquintinib + S-1 + OxaliplatinFruquintinib + Tegafur/Gimeracil/Oteracil + Oxaliplatin
02
Targets
DNADPYD (Dihydropyrimidine dehydrogenase)FGFR1 (Fibroblast growth factor receptor 1)OPRT (Orotidine 5'-phosphate decarboxylase)RET (Rearranged during transfection receptor tyrosine kinase)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)
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