frusemide + indomethacin

This is a combination of two small molecule drugs, frusemide (also known as furosemide) and indomethacin. Frusemide is a loop diuretic that inhibits the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle, leading to increased excretion of sodium, chloride, and water. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin synthesis and exerting anti-inflammatory, analgesic, and antipyretic effects. When used together, indomethacin can blunt or reduce the natriuretic (sodium-excreting) and antihypertensive effects of frusemide by inhibiting renal prostaglandin synthesis[1][2][6]. This interaction may be clinically significant in conditions such as heart failure or when both drugs are required for specific indications like patent ductus arteriosus closure in neonates[1][3].