FSL-1

FSL-1 is a synthetic lipopeptide that acts as a potent and selective agonist of the Toll-like receptor 2 and Toll-like receptor 6 (TLR2/TLR6) heterodimer. It mimics the N-terminal part of a 44-kDa lipoprotein from Mycoplasma salivarium and contains a diacylated cysteine residue. Once recognized by TLR2/TLR6, FSL-1 induces the MyD88-dependent activation of transcription factors NF-κB and AP-1, resulting in the upregulation of proinflammatory cytokines such as TNF-α, IL-1α, G-CSF, and chemokines. Preclinical models show FSL-1 confers radioprotection and radiomitigation, enhances hematopoietic recovery, reduces inflammation, and can increase resistance to viral infection including HSV-2. Its mechanism involves both promoting innate immune responses and supporting hematopoietic recovery following radiation damage[1][2][3][4][5][6][7][8][9].

Other names

fibroblast-stimulating lipopeptide 1synthetic diacylated lipoproteinTLR2/6 agonistFSL-1 (trifluoroacetate salt)