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FT516 + avelumab
- Development stage
- Discontinued
- Lead developer
- Fate Therapeutics
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
FT516 + avelumab is an investigational **combination therapy** comprised of FT516, an engineered “off-the-shelf” natural killer (NK) cell product derived from genetically modified human induced pluripotent stem cells (iPSC), and avelumab, a fully human IgG1 monoclonal antibody targeting programmed death-ligand 1 (PD-L1). FT516 has enhanced expression of high-affinity CD16a and resistance to ADAM17 cleavage to increase NK cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab acts as a PD-L1 checkpoint inhibitor and enables further ADCC through engagement of immune effector cells. The combination is designed to synergistically target and eliminate cancer cells via both immune checkpoint blockade and boosted NK cell activity, particularly in advanced solid tumors[1][5][6].
- Other names
- FT516 + avelumab
02
Targets
FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)CD274 (Programmed cell death protein 1 ligand 1)
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