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Fu-Fang-Qi-Di-Hua-Yu-Tang
- Development stage
- Preclinical
- Administration
- Oral
01
Overview
Fu-Fang-Qi-Di-Hua-Yu-Tang (FFQD) is a multi-component traditional Chinese medicine (TCM) herbal formulation. It has been studied primarily for its effects on diabetic macrovascular disease, with demonstrated actions in reducing atherosclerosis, improving insulin resistance, and regulating glucose and lipid metabolism in preclinical models. FFQD acts by modulating multiple targets and pathways, notably inhibiting inflammation (reducing TNF-alpha, IL-6, IL-1beta, CRP, MCP-1), oxidative stress, and autophagy, while regulating macrophage polarization and activating the PI3K/AKT pathway both in vascular tissue and liver. It also positively influences the RAGE/PI3K/AKT/mTOR pathway in vessels and the RAP1/PI3K/AKT/FOX01 pathway in the liver, collectively leading to improved vascular and metabolic outcomes in type 2 diabetes models. FFQD comprises at least 159 identified phytochemical components[2][1][6].
- Other names
- FFQDFuFang QiDi HuaYu Tang
02
Targets
FOXO1 (Forkhead box protein O1)NOS2 (Nitric Oxide Synthase 2)IL-6 (Interleukin 6)NF-κBRAP1PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)TNFA (Tumor necrosis factor alpha (soluble))mTOR (Mammalian target of rapamycin kinase)IL1B (Interleukin-1 beta)
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