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Fu-Zheng-Qu-Zhuo (FZQZ) is a traditional Chinese medicine (TCM) formulation primarily used as an adjunct therapy for patients with stage 3–4 chronic kidney disease (CKD). It is typically administered as an oral liquid and is often combined with standard integrated therapies. Clinical studies have shown that FZQZ can slow the progression of CKD, reduce the occurrence of composite endpoint events such as initiation of dialysis, doubling of serum creatinine, or CKD-related death, and improve patient-reported symptoms like appetite and physical function. The mechanism of action is not fully elucidated but may involve improving liver and spleen function to enhance organic immunity. Common herbal components include rhubarb (dahuang), Astragalus membranaceus (huangqi), and Angelica sinensis (danggui)[1][2][3][5]. Safety data indicate no significant increase in adverse events compared to placebo[1].
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