Fudan Univ. Keap1 compound 6 K

Fudan Univ. Keap1 compound 6 K: sourced facts only. name: "The piperazinyl-naphthalenesulfonamide 6 K was reported to be a Keap1-Nrf2 protein-protein interaction inhibitor, showing promising antioxidative effect." [PMID:36681044]; target: "The piperazinyl-naphthalenesulfonamide 6 K was reported to be a Keap1-Nrf2 protein-protein interaction inhibitor, showing promising antioxidative effect." [PMID:36681044]; developer: "Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China; National Center for Neurological Disorders, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, China; Neurosurgical Institute of Fudan University, China; Shanghai Clinical Medical Center of Neurosurgery, China; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, China." [PMID:36681044]; modality: "Targeting Keap1-Nrf2 interaction by small molecules to release Nrf2 should be a promising strategy to treat cerebral I/R injury." [PMID:36681044]; stage: "The results indicated that treatment of 6 K markedly decreased infarct volume, apoptotic neurons and oxidative damage and promoted neurologic recovery in vivo." [PMID:36681044]