Drug intelligence / Profile preview

fufang banmao capsule

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral
01

Overview

Fufang Banmao Capsule is a **traditional Chinese medicine (TCM) combination product** consisting of extracts from 11 medicinal ingredients, the principal component being *Banmao* (Mylabris), whose active compound is **cantharidin**. Cantharidin is an inhibitor of protein phosphatase 2A (PP2A), inducing cell cycle arrest and apoptosis via multiple mechanisms, including interference with the JNK/Sp1 signaling pathway and regulatory proteins such as p53 and cyclins. Additional bioactive compounds in the capsule, such as ginsenosides and astragalosides, exert anti-tumor, immunomodulatory, and anti-metastatic effects through pathways including NRF2/HO-1 and VEGF/VEGF-R2 signaling. The product is used mainly as **an adjuvant or combined anti-cancer therapy**, chiefly for primary liver cancer (hepatocellular carcinoma, HCC), but there is clinical evidence for its use in other advanced malignancies for improving quality of life (QOL), symptom control, and reducing chemotherapy toxicity. It is approved by the China Food and Drug Administration as an anti-cancer drug[1][3][5][7].

Brand names
Fufang Banmao Capsule
Other names
FFBMmultifraction cantharides capsulecomposite cantharides capsule
02

Targets

HSF1 (Heat shock factor protein 1)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)PIK3CA (Phosphoinositide 3-kinase alpha)PP2A (Protein phosphatase 2A)TNFA (Tumor necrosis factor alpha (soluble))VEGFR2 (Vascular endothelial growth factor receptor 2)

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