Drug intelligence / Profile preview

Fufang Danshen

Development stage
Phase 2
Lead developer
Tasly Pharmaceutical
Administration
Oral, Sublingual
01

Overview

Fufang Danshen is a traditional Chinese medicine (TCM) multi-herb formulation primarily used for cardiovascular and circulatory health. The most common formulations include Fufang Danshen Tablet and Compounded Danshen Dripping Pill. The main active ingredients are Salvia miltiorrhiza (Danshen), Panax notoginseng (San Qi), and Styrax (Su He Xiang). Mechanistically, it acts through multiple pathways including anti-inflammatory effects (inhibiting TNF-α and IL-6), antioxidation, anticoagulation, anti-apoptosis in cardiac tissue, inhibition of monocyte recruitment via regulation of Selp and Ccl2 expression in vascular endothelium, improvement of blood flow by dissolving blood stasis and dispersing phlegm turbidity. It has been clinically used for over 40 years to treat coronary artery disease (CAD), angina pectoris, atherosclerosis and other cardiovascular diseases. Studies suggest it can improve lipid profiles and reduce neuroinflammation[4][5][6].

Brand names
Fu Fang Dan ShenFufang Danshen TabletFu Fang Dan Shen PianCompounded Danshen Dripping PillCardiovigor
Other names
Compound Danshen TabletCompound Danshen Dripping PillCDDP
02

Targets

IL-6 (Interleukin 6)CCL2 (C-C motif chemokine 2)TNFA (Tumor necrosis factor alpha (soluble))SELP (P-selectin)

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