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fufang danshen tablet

Development stage: Unknown
Lead developer: First Affiliated Hospital of Guangzhou University of Chinese Medicine
Modality: Small Molecules
Administration: Oral

Overview

Fu Fang Danshen Tablet (FDT) is a traditional Chinese medicine (TCM) herbal compound formulation that has been clinically utilized for over 40 years, primarily in China, for the treatment of cardiovascular diseases. The formulation consists of three main ingredients: *Salvia miltiorrhiza* (Danshen), *Panax notoginseng* (Notoginseng), and synthetic borneol. Its therapeutic effects are attributed to bioactive compounds such as salvianolic acids and phenolic acids, which provide antioxidant, anti-inflammatory, and antithrombotic benefits. FDT is currently being investigated in Phase 4 clinical trials to evaluate its efficacy in improving cardiac function in patients with acute myocardial infarction following emergency percutaneous coronary intervention (PCI). It is also used to manage angina pectoris, coronary heart disease, and atherosclerosis by modulating pathways related to oxidative stress, cell apoptosis (targeting Bcl-2, Bax, and caspase 3), and immune regulation.

Brand names: Fu Fang Danshen Tablet
Other names: Fufang Danshen TabletCompound Danshen Tablet

Targets

BAX (Apoptosis regulator BAX)JNK (Mitogen-activated protein kinase kinase kinase family)MAPK14 (p38 mitogen-activated protein kinase alpha)CASP3 (Caspase-3)

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