Drug intelligence / Profile preview

fufang jiangya pian

Development stage
Unknown
Lead developer
Fuwai Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

Fufang Jiangya Pian (Compound Antihypertensive Tablet) is a traditional fixed-dose combination (FDC) medication widely utilized in China for the management of mild to moderate hypertension. The formulation typically integrates several active pharmaceutical ingredients with distinct mechanisms: reserpine (a vesicular monoamine transporter inhibitor that depletes catecholamines), dihydralazine (a direct-acting peripheral vasodilator), and hydrochlorothiazide (a thiazide diuretic that reduces blood volume). It also frequently contains promethazine for its mild sedative effects and various vitamins (B1, B6) and minerals (potassium, magnesium) to mitigate potential side effects and support metabolic health. Developed and utilized extensively within the Chinese healthcare system, particularly in community settings, it offers a cost-effective strategy for long-term blood pressure management. It has been the subject of large-scale clinical trials, such as those conducted by Fuwai Hospital, to evaluate its efficacy and compliance in primary care.

Brand names
Fufang Jiangya Pian
Other names
Compound Antihypertensive Tablet复方降压片Compound Reserpine Tablets
02

Targets

VMAT1 (Vesicular monoamine transporter type 1)VMAT2 (Vesicular monoamine transporter 2)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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