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Drug intelligence / Profile preview
fuling sini decoction
- Development stage
- Unknown
- Lead developer
- Beijing University of Chinese Medicine Shenzhen Hospital
- Administration
- Oral
01
Overview
Fuling Sini Decoction is a Traditional Chinese Medicine (TCM) herbal formula traditionally used to treat conditions characterized by Yang exhaustion and fluid retention. It is a modification of the classic Sini Decoction, typically comprising *Poria cocos* (Fuling), *Aconitum carmichaelii* (Fuzi), *Zingiber officinale* (Ganjiang), *Glycyrrhiza uralensis* (Gancao), and *Panax ginseng* (Renshen). In modern clinical research, it is being investigated for its potential to treat septic cardiomyopathy and immune paralysis. The formula is hypothesized to promote myocardial repair and modulate immune responses in the context of sepsis-induced heart dysfunction by improving immune paralysis and enhancing cardiac energy metabolism.
- Brand names
- Fuling Sini Decoction
- Other names
- Fuling Sini Tang茯苓四逆汤
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CASP3 (Caspase-3)IL-6 (Interleukin 6)STAT3 (Signal Transducer and Activator of Transcription 3)SMAD2 (Mothers against decapentaplegic homolog 2)TGFB1 (Transforming growth factor Beta-1 proprotein)TNFA (Tumor necrosis factor alpha (soluble))
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