Drug intelligence / Profile preview

fuling sini decoction

Development stage
Unknown
Lead developer
Beijing University of Chinese Medicine Shenzhen Hospital
Administration
Oral
01

Overview

Fuling Sini Decoction is a Traditional Chinese Medicine (TCM) herbal formula traditionally used to treat conditions characterized by Yang exhaustion and fluid retention. It is a modification of the classic Sini Decoction, typically comprising *Poria cocos* (Fuling), *Aconitum carmichaelii* (Fuzi), *Zingiber officinale* (Ganjiang), *Glycyrrhiza uralensis* (Gancao), and *Panax ginseng* (Renshen). In modern clinical research, it is being investigated for its potential to treat septic cardiomyopathy and immune paralysis. The formula is hypothesized to promote myocardial repair and modulate immune responses in the context of sepsis-induced heart dysfunction by improving immune paralysis and enhancing cardiac energy metabolism.

Brand names
Fuling Sini Decoction
Other names
Fuling Sini Tang茯苓四逆汤
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)TGFB1 (Transforming growth factor Beta-1 proprotein)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TNFA (Tumor necrosis factor alpha (soluble))SMAD2 (Mothers against decapentaplegic homolog 2)CASP3 (Caspase-3)

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