Drug intelligence / Profile preview

fuling zexie tang

Development stage
Unknown
Administration
Oral
01

Overview

Fuling Zexie Tang (茯苓泽泻汤), also known as Poria and Alisma Decoction, is a classical herbal formula from Traditional Chinese Medicine (TCM). It originates from ancient TCM texts attributed to Dr. Zhang Zhongjing over 2000 years ago. The formula is used primarily for conditions involving water metabolism disorders, such as edema or urinary difficulty, often associated with spleen deficiency and dampness accumulation. Its main actions are to promote urination, resolve dampness, strengthen the spleen, and support fluid metabolism in the body[1][8]. The mechanism of action is based on synergistic effects of its herbal components—typically including Poria (Fu Ling) and Alisma (Ze Xie)—which act to increase diuresis and regulate water pathways according to TCM theory. This formula does not have a defined molecular target in Western pharmacology but works through multi-component herbal synergy affecting fluid balance[1][8].

Other names
茯苓泽泻汤Poria and Alisma Decoction
02

Targets

OAT1 (Organic anion transporter 1)SLC22A8 (Organic anion transporter 3)URAT1 (Uric Acid Transporter 1)GLUT9 (Glucose transporter type 9)TLR4 (Toll-like receptor 4)ABCG2 (Breast cancer resistance protein)

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