Fumagillin

Fumagillin is a natural product originally isolated from the fungus Aspergillus fumigatus in 1949. It is a meroterpenoid compound with antimicrobial properties and has been primarily used as an agent to control Nosema infections (nosemosis) in honey bees. In veterinary use, it targets microsporidian parasites such as Nosema apis and Nosema ceranae. In humans, fumagillin has been used for the treatment of microsporidiosis and as an amebicide. Mechanistically, it acts by irreversibly inhibiting methionine aminopeptidase 2 (MetAP2), which blocks blood vessel formation (angiogenesis). This anti-angiogenic property has led to investigation of fumagillin and its analogs for potential cancer therapy[1][4][5][6][8]. However, its clinical use in humans is limited due to toxicity concerns.

Brand names

Fumidil-BFumagilin-B

Other names

bicyclohexylammonium fumagillin23110-15-8