furamidine

Furamidine (DB75) is a synthetic diamidine compound with potent antiparasitic activity, primarily known as the active metabolite of the oral prodrug pafuramidine (DB289)[1][2][3][4][5]. Furamidine exerts its trypanocidal effect by binding to the minor groove of DNA, thereby interfering with essential genetic processes in protozoal organisms[5]. It has demonstrated broad-spectrum activity against African trypanosomes, Pneumocystis jirovecii, Plasmodium spp. (malaria), and certain fungal pathogens[1][2][3][5]. The drug disrupts mitochondrial function in susceptible cells; yeast cells reliant on mitochondrial metabolism show particular sensitivity[3]. Furamidine is considered experimental and is not currently approved as a marketed pharmaceutical[1][3].

Other names

2,5-bis(4-amidinophenyl)furan