furanodienone

Furanodienone (FDN) is a naturally occurring furanosesquiterpenoid isolated from plants such as *Rhizoma Curcumae* (zedoary) and ginger (*Zingiber officinale*). It has been investigated for its anti-inflammatory, anticancer, and antimicrobial properties. In oncology, furanodienone has been shown to inhibit cell proliferation and induce apoptosis in breast cancer, colorectal cancer, and non-small cell lung cancer cells, primarily by suppressing estrogen receptor alpha (ERα) signaling, downregulating EGFR/HER2 pathways, and promoting reactive oxygen species (ROS) generation. More recently, researchers at the University of Toronto identified furanodienone as a selective agonist of the pregnane X receptor (PXR) in the gut, demonstrating its potential to alleviate intestinal inflammation and repair gut barrier integrity in preclinical models of inflammatory bowel disease (IBD) without causing systemic side effects.

Other names

(5E,9E)-3,6,10-trimethyl-7,8-dihydrocyclodeca[b]furan-4(11H)-one(5E,9E)-8,11-dihydro-3,6,10-trimethylcyclodeca[b]furan-4(7H)-one(5Z,9Z)-3,6,10-trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one3,6,10-trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-oneFDNfuranodienon