furosemide (SQ Innovation, Inc.)

SQIN-furosemide (Lasix ONYU) is a novel, pH-neutral, high-concentration subcutaneous formulation of the loop diuretic furosemide, developed by SQ Innovation. It is designed as a drug-device combination product for at-home self-administration via a wearable abdominal patch infusor (SQIN-Infusor). The formulation is specifically engineered to be pH-neutral to minimize skin irritation, a common limitation of standard alkaline furosemide preparations. It is indicated for the treatment of edema associated with fluid overload in adult patients with chronic heart failure. By inhibiting the Na-K-2Cl cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, it promotes diuresis and natriuresis with bioavailability comparable to intravenous administration, potentially reducing the need for hospitalizations.

Brand names

Lasix ONYU

Other names

SQIN-Furosemide