furosemide + spironolactone

Furosemide + spironolactone is a fixed-dose combination of two diuretics used primarily to treat edema (fluid overload) associated with heart failure, liver cirrhosis, kidney disease, or lung disease, as well as for the management of hypertension in certain cases. Furosemide is a loop diuretic that inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, leading to increased excretion of water and electrolytes. Spironolactone is a potassium-sparing diuretic and aldosterone antagonist that blocks mineralocorticoid receptors in the distal nephron, promoting sodium excretion while conserving potassium. The combination provides synergistic diuresis while minimizing potassium loss compared to furosemide alone[1][2][3][10].

Brand names

LasilactoneFruselacSpiromideMinilactoneAmifru-SAldostixAldolocLasfru SDiutonDilupDireticDiretic-DSEdelossEdeloss Plus

Other names

furosemide and spironolactone