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FUSE501
- Development stage
- Preclinical
- Lead developer
- Fusix Biotech
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Gene Silencing → Gene Therapies, Oncolytic Viruses → Oncolytic Therapeutics, Gene Editing → Gene Therapies, Gene Addition/Replacement → Gene Therapies
- Administration
- Intravenous
01
Overview
FUSE501 is a preclinical-stage therapeutic candidate developed by Fusix Biotech for the treatment of solid tumors. It utilizes the company's proprietary InFUSE platform, which consists of an oncolytic viral vector engineered to encode a bispecific antibody construct. This approach combines the direct tumor-lytic properties of the oncolytic virus with the targeted immune-modulating or anti-tumor activity of the encoded bispecific antibody, which is expressed locally within the tumor microenvironment upon viral infection. The specific molecular targets of the bispecific antibody have not been disclosed.
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