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Drug intelligence / Profile preview
fushen
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Fushen is a specialized medicinal part of the fungus *Poria cocos* (Schw.) Wolf, specifically referring to the sclerotium that has grown around and contains a portion of the host pine root (*Pinus* spp.). It is distinguished in Traditional Chinese Medicine (TCM) from other parts of the *Poria* fungus (such as Fuling or Poria Cutis) by its specific mind-tranquilizing and sedative properties. Bioactive components include triterpenoids (such as pachymic acid and dehydroeburicoic acid) and polysaccharides. Research indicates that Fushen exerts therapeutic effects by modulating the 5-hydroxytryptamine (5-HT) and GABAergic systems for insomnia, and by inhibiting inflammatory and oxidative stress pathways such as TLR4/NF-κB, p38MAPK, and Nrf2/HO-1 in the context of chronic renal failure and peritoneal dialysis-related peritonitis. It is also noted for its ability to regulate gut microbiota and protect the intestinal barrier.
- Brand names
- Fushen GranuleFushen DecoctionFushen Wan
- Other names
- Poria cum Radix PiniPoria cum Ligno HospitePoria cocos (Schw.) Wolf (Fushen)Poria cocos sclerotium with pine root
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HMOX1 (Heme oxygenase 1)NF-κBNFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)TLR4 (Toll-like receptor 4)TPH2 (Tryptophan hydroxylase 2)RK (Ribokinase)MAPK14 (p38 mitogen-activated protein kinase alpha)
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