Drug intelligence / Profile preview

Fusihalt

Development stage
Unknown
Lead developer
Melinta Therapeutics
Modality
Small Molecules
Administration
Topical
01

Overview

Fusihalt is a topical antibiotic cream marketed by VTS Life Sciences, containing fusidic acid at a concentration of 2% w/w. Fusidic acid is a bacteriostatic antibiotic that inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the bacterial ribosome, which prevents the release of the EF-G-GDP complex and halts the translocation step of translation. It is primarily indicated for the treatment of superficial skin infections caused by susceptible Gram-positive bacteria, most notably *Staphylococcus aureus* (including methicillin-resistant strains) and *Streptococcus* species. Common clinical uses include the treatment of impetigo, folliculitis, erythrasma, and secondary infections in dermatitis. Although sometimes categorized within antifungal or broad dermatological portfolios in marketing contexts, its primary therapeutic activity is antibacterial.

Brand names
Fusihalt
Other names
Fusidic acid cream
02

Targets

EF-G (Elongation factor G 1, mitochondrial)CYP3A (CYP3A family)OATP1B1 (Organic anion transporting polypeptide 1B1)ABCG2 (Breast cancer resistance protein)

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