Drug intelligence / Profile preview

Fuzheng Jiedu Huayu

Development stage
Unknown
Lead developer
Beijing Ditan Hospital
Administration
Oral
01

Overview

Fuzheng Jiedu Huayu is a traditional Chinese medicine (TCM) herbal formulation developed by Beijing Ditan Hospital. It is used primarily for the prevention and treatment of tumors and infectious diseases, as well as certain digestive system disorders. The decoction is composed of multiple herbs with purported effects such as "invigorating qi," "detoxification," and "removing blood stasis." Mechanistically, it has demonstrated antibacterial activity against multidrug-resistant Pseudomonas aeruginosa by inhibiting biofilm formation through suppression of the MexAB-OprM efflux pump and quorum sensing systems. Clinical studies suggest it can enhance the efficacy of antibiotics in pneumonia and may reduce toxicity while improving outcomes when combined with immunotherapy or antiviral agents in hepatitis B virus-related hepatocellular carcinoma. Its active components include quercetin, baicalein, luteolin, kaempferol, and β-sitosterol[1][2][3][6][8].

Brand names
Huashi Baidu Granules
Other names
Fuzheng Jiedu Huayu DecoctionFuzheng Touxie Jiedu Huayu Decoction (variant)Fu Zheng Jie Du Hua Yu Principle
02

Targets

Quorum-sensing system of Pseudomonas aeruginosaMexAB-OprM efflux pump regulatory proteins

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