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Fuzheng Tongfu Jiedu
- Development stage
- Phase 2
- Lead developer
- Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Fuzheng Tongfu Jiedu (FZTFJD) is a Traditional Chinese Medicine (TCM) prescription developed for the treatment of gastrointestinal dysfunction associated with sepsis, particularly Acute Gastrointestinal Injury (AGI) grades I-III. The formulation is based on the therapeutic principles of strengthening body resistance ("Fuzheng"), unblocking the bowels/viscera ("Tongfu"), and detoxification ("Jiedu"). It is administered as an adjunctive therapy alongside conventional Western medicine to improve intestinal barrier function, alleviate gut symptoms, reduce abdominal pressure, and lower systemic inflammation levels. Clinical evaluation focuses on its ability to improve AGI grading and prognostic indicators like ICU stay and 28-day mortality.
- Brand names
- Fuzheng Tongfu Jiedu prescription
- Other names
- Fuzheng Tongfu Jiedu PrescriptionFuzheng Tongfu Jiedu Decoction
02
Targets
NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)CASP1 (Caspase-1)GSDMD (Gasdermin D)
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