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Fuzheng Tongge formula
- Development stage
- Unknown
- Lead developer
- China-Japan Friendship Hospital
- Administration
- Oral
01
Overview
Fuzheng Tongge formula is a Traditional Chinese Medicine (TCM) decoction developed by the China-Japan Friendship Hospital. It is primarily investigated as a neoadjuvant therapy in combination with PD-1 monoclonal antibodies and chemotherapy for the treatment of locally advanced, long-lesion esophageal squamous cell carcinoma (ESCC). The formula is designed to modulate the tumor microenvironment, specifically targeting the balance of TCF-1+ and TCF-1- CD8+ T cells. Research suggests that patients with a low TCF-1+/TCF-1- ratio among CD8+ T cells in the tumor microenvironment may derive particular benefit from the addition of this herbal formula to standard immunotherapy regimens, potentially enhancing the anti-tumor immune response and improving pathological complete response rates.
- Other names
- Fuzheng Tongge decoctionFuzheng Tongge recipe
02
Targets
CD8A (CD8 alpha/beta Coreceptor)HNF1A (Hepatocyte nuclear factor 1-alpha)
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