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Fuzheng Xiaoliu Granules

Development stage
Preclinical
Lead developer
First Affiliated Hospital of Henan University of Chinese Medicine
Administration
Oral
01

Overview

Fuzheng Xiaoliu Granules (also known as No.I Fuzheng Xiaoliu Granules or FZXLG) is a traditional Chinese medicine (TCM) herbal preparation developed as an intra-hospital prescription by the First Affiliated Hospital of Henan University of Chinese Medicine. The formulation is composed of 12 traditional Chinese medicinal herbs, including Radix Astragali, Smilax china, Codonopsis Radix, Atractylodes macrocephala, Paeoniae Radix Alba, Salvia Miltiorrhiza, Carapax Trionycis, Concha Ostreae, Actinidia valvata, Citri Reticulatae Pericarpium, Radix Bupleuri, and Glycyrrhiza uralensis. It is primarily developed for the treatment of hepatocellular carcinoma (HCC) and hepatitis B virus (HBV) infection, particularly to reduce recurrence rates in patients with early-stage HBV-related HCC after comprehensive minimally invasive surgery or ablation. Fuzheng Xiaoliu Granules is believed to exert its therapeutic effects through multi-component, multi-target, and multi-pathway mechanisms, including the regulation of lipid metabolism, immune microenvironment modulation, and inhibition of tumor cell proliferation.

Other names
FZXLGFuzheng Xiaoliu GranuleFuzheng Xiaolu GranulesNo. I Fuzheng Xiaoliu GranulesNo.I Fuzheng Xiaoliu Granules
02

Targets

CAT (Catalase)BCL-2 (BCL-2 family)CDK1 (Cyclin-dependent kinase 1)ESR1 (ERα)TP53 (Cellular Tumor Antigen p53 R175H)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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