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Fuzheng Xiaoliu Granules II
- Development stage
- Preclinical
- Lead developer
- First Affiliated Hospital of Henan University of Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Fuzheng Xiaoliu Granules II is a traditional Chinese medicine (TCM) herbal formulation developed by the First Affiliated Hospital of Henan University of Chinese Medicine. It is formulated based on the principles of strengthening the body's resistance (Fuzheng) and eliminating tumors (Xiaoliu), specifically targeting deficiency of vital qi and blood stasis syndrome. The formulation is primarily investigated for the treatment of stage II hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) following comprehensive minimally invasive therapy (such as transcatheter arterial chemoembolization and radiofrequency ablation). Clinical studies suggest that Fuzheng Xiaoliu Granules II can reduce the recurrence rate, improve the quality of life, and modulate lipid metabolism and immune function in patients with hepatocellular carcinoma.
- Other names
- Fuzheng Xiaoliu Granule IIFuzheng Xiaoliu Granules II号方Fuzheng Xiaoliu II扶正消瘤2号扶正消瘤颗粒2号扶正消瘤颗粒II号扶正消瘤颗粒II号方
02
Targets
JUN (Transcription factor Jun)IL-6 (Interleukin 6)PDCD1 (Programmed cell death protein 1 receptor)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)ESR1 (ERα)
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