Drug intelligence / Profile preview

fuzheng yiliu

Development stage
Phase 2
Lead developer
Guangdong Provincial Hospital of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Fuzheng Yiliu is a traditional Chinese medicine (TCM) multi-herbal formulation used primarily as an adjunctive therapy in cancer treatment. It contains a combination of herbs such as Raw land (possibly Rehmannia), Zhimu (Anemarrhena), raw jaundice (likely Scutellaria or Coptis), fairy spleen, Bayu Tian (Morinda officinalis), Quanqi (Astragalus membranaceus), Atractylodes, Poria, Licorice, Cork (Phellodendron bark), American ginseng, Tortoiseshell and Hedyotis diffusa[1][2]. The formula is designed to "strengthen the body's righteous energy" and inhibit tumor growth according to TCM principles. Modern studies suggest it has anti-inflammatory, immunomodulatory and antineoplastic effects[1][3][7]. Mechanistically it acts through multiple bioactive compounds—such as quercetin—which have been shown to suppress tumor cell proliferation and migration by modulating pathways like PI3K/AKT and MAPK/STAT3 signaling[3][9]. Clinical research indicates that Fuzheng Yiliu can enhance the efficacy of chemotherapy or ablation therapies in cancers such as colorectal cancer[5], hepatocellular carcinoma[6], prostate cancer[3][8], gastrointestinal tumors[7], and pediatric malignancies[9] by improving immune function and reducing side effects. It is typically administered orally in granule or decoction form.

Brand names
fuzheng yiliu
Other names
fuzheng yiliu decoctionFZYLDFuzheng Yiliu RecipeFuzheng Yiliu Formula
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)STAT3 (Signal Transducer and Activator of Transcription 3)PIK3CA (Phosphoinositide 3-kinase alpha)

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