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Fuzhuan brick tea polysaccharide refers to a group of acidic heteropolysaccharides isolated from Fuzhuan (Fu) brick tea, a traditional Chinese fermented dark tea. The main composition includes monosaccharides such as mannose, rhamnose, galacturonic acid, glucose, galactose, and arabinose, and molecular weight varies by extraction method. These polysaccharides are a major bioactive ingredient of the tea and are reported to have potent immunomodulatory, antioxidant, and prebiotic effects. Mechanistically, they regulate the gut microbiota—promoting the abundance of beneficial bacteria (such as Lactobacillus, Bifidobacteriaceae, Prevotellaceae, and Akkermansia) and suppressing pathogenic bacteria, with increased production of short-chain fatty acids. They have demonstrated ability to modulate immune response by stimulating macrophage activity, reducing inflammation, and repairing intestinal mucosa, improving outcomes in animal models of ulcerative colitis, metabolic syndrome (such as hyperglycemia and hyperlipidemia), and oxidative injury. Fuzhuan brick tea polysaccharides are commonly researched for potential use as novel prebiotics, immunomodulators, and functional food ingredients for prevention or adjunct therapy in metabolic and inflammatory diseases[1][2][3][4][5][6][7][8].
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